Casa Italiana, one of three New York City landmarks on campus, is home to the Italian Academy for Advanced Studies in America. It is one of many buildings on campus designed by the renowned architectural firm of McKim, Meade and White. It was restored in 1993 based on the designs of Italian architect Italo Rota of Paris and Milan and Samuel E. White of Buttrick, White & Burtis of New York.

Founded in 1991 on the basis of an agreement between the Republic of Italy and Columbia University, the Academy promotes advanced research in all areas relating to Italian history and society. In addition, it seeks to establish a high level of academic and cultural exchange between Italy and the US.